Gail E Sonenshein Selected Research

Protein-Lysine 6-Oxidase (Lysyl Oxidase)

1/2018	A polymorphism in the lysyl oxidase propeptide domain accelerates carcinogen-induced cancer.
1/2013	Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide.
1/2012	Blimp1 activation by AP-1 in human lung cancer cells promotes a migratory phenotype and is inhibited by the lysyl oxidase propeptide.
1/2012	Recombinant lysyl oxidase propeptide protein inhibits growth and promotes apoptosis of pre-existing murine breast cancer xenografts.
8/2011	The lysyl oxidase propeptide interacts with the receptor-type protein tyrosine phosphatase kappa and inhibits β-catenin transcriptional activity in lung cancer cells.
7/2011	The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells.
12/2010	Lysyl oxidase propeptide sensitizes pancreatic and breast cancer cells to doxorubicin-induced apoptosis.
4/2010	Characterization of recombinant lysyl oxidase propeptide.
8/2009	A loss-of-function polymorphism in the propeptide domain of the LOX gene and breast cancer.
1/2009	The lysyl oxidase pro-peptide attenuates fibronectin-mediated activation of focal adhesion kinase and p130Cas in breast cancer cells.

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Gail E Sonenshein Research Topics

Disease

35	Neoplasms (Cancer) 01/2018 - 02/2002
29	Breast Neoplasms (Breast Cancer) 01/2018 - 02/2002
9	Carcinogenesis 07/2009 - 08/2003
4	Prostatic Neoplasms (Prostate Cancer) 01/2017 - 08/2008
3	Lung Neoplasms (Lung Cancer) 01/2012 - 07/2007
3	Carcinoma (Carcinomatosis) 12/2010 - 08/2003
3	Pancreatic Neoplasms (Pancreatic Cancer) 12/2010 - 07/2007
3	Lymphoma (Lymphomas) 08/2008 - 05/2004
2	Triple Negative Breast Neoplasms 04/2016 - 11/2014
2	Neoplasm Metastasis (Metastasis) 03/2016 - 11/2014
2	Breast Diseases (Breast Disease) 06/2007 - 04/2007
2	Hepatocellular Carcinoma (Hepatoma) 12/2003 - 01/2003
1	Inflammatory Breast Neoplasms 01/2013
1	Lymphoid Leukemia 01/2013
1	Glioblastoma (Glioblastoma Multiforme) 01/2012
1	Pancreatic Ductal Carcinoma 01/2012
1	Adenocarcinoma of Lung 01/2012
1	Stomach Neoplasms (Stomach Cancer) 08/2009
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 08/2008
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 08/2008
1	Pleural Effusion (Pleural Effusions) 10/2007
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 06/2007
1	Retinoblastoma (Glioblastoma, Retinal) 01/2005

Drug/Important Bio-Agent (IBA)

19	NF-kappa B (NF-kB)IBA 09/2009 - 11/2002
13	Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA 01/2018 - 09/2004
8	Proteins (Proteins, Gene)FDA Link 01/2017 - 06/2008
8	PolyphenolsIBA 01/2013 - 02/2002
8	TeaIBA 01/2013 - 02/2002
7	CarcinogensIBA 01/2018 - 01/2005
6	Estrogen Receptor alphaIBA 01/2017 - 10/2004
6	Phosphotransferases (Kinase)IBA 12/2010 - 11/2002
6	AgarIBA 07/2007 - 11/2002
4	9,10-Dimethyl-1,2-benzanthraceneIBA 01/2018 - 11/2005
4	RNA (Ribonucleic Acid)IBA 12/2012 - 12/2007
4	Cyclin D1IBA 12/2010 - 01/2005
4	Casein Kinase II (Casein Kinase 2)IBA 12/2007 - 11/2002
4	Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)IBA 12/2007 - 01/2005
4	ErbB Receptors (EGF Receptor)IBA 10/2007 - 02/2002
3	matrigelIBA 01/2013 - 12/2005
3	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 05/2008 - 01/2005
2	Enzyme Precursors (Zymogens)IBA 01/2018 - 08/2011
2	DisintegrinsIBA 04/2016 - 11/2014
2	Metalloproteases (Metalloproteinases)IBA 04/2016 - 11/2014
2	Estrogen ReceptorsIBA 11/2014 - 08/2009
2	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 01/2013 - 06/2007
2	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 01/2012 - 04/2007
2	Biological ProductsIBA 12/2010 - 04/2010
2	Immunoglobulin M (IgM)IBA 08/2008 - 06/2007
2	Environmental CarcinogensIBA 05/2008 - 01/2005
2	Transcription Factors (Transcription Factor)IBA 05/2008 - 12/2005
2	Environmental Pollutants (Pollutants, Environmental)IBA 12/2007 - 08/2005
2	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 07/2007 - 02/2007
2	I-kappa B KinaseIBA 12/2005 - 12/2003
2	anthraceneIBA 12/2005 - 01/2005
2	Complementary DNA (cDNA)IBA 12/2005 - 08/2003
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 10/2004 - 11/2002
2	Cyclin-Dependent Kinases (cdk Proteins)IBA 05/2004 - 04/2003
2	Transforming Growth Factor beta1 (TGF beta 1)IBA 12/2003 - 01/2003
1	Arginine (L-Arginine)FDA Link 01/2018
1	Progesterone FDA LinkGeneric 01/2018
1	Androgen Receptors (Androgen Receptor)IBA 01/2017
1	Vascular Endothelial Growth Factor DIBA 01/2013
1	Bone Morphogenetic Protein 5IBA 12/2012
1	Delayed-Action PreparationsIBA 01/2012
1	Protein Tyrosine PhosphatasesIBA 08/2011
1	CateninsIBA 08/2011
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 07/2011
1	Annexin A5IBA 12/2010
1	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2010
1	Adenosine Triphosphate (ATP)IBA 12/2010
1	tyrosine receptor (receptor, tyrosine)IBA 12/2010
1	Caspase 3 (Caspase-3)IBA 12/2010
1	EnzymesIBA 04/2010
1	25-hydroxyvitamin DIBA 09/2009
1	Calcitriol (Calcijex)FDA LinkGeneric 09/2009
1	human ERBB2 proteinIBA 08/2009
1	Peptides (Polypeptides)IBA 01/2009
1	Tyrosine (L-Tyrosine)FDA Link 01/2009
1	Fibronectins (Fibronectin)IBA 01/2009
1	Focal Adhesion Protein-Tyrosine KinasesIBA 01/2009
1	anti-IgMIBA 08/2008
1	Cytochrome P-450 CYP1A1 (CYP1A1)IBA 05/2008
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 05/2008
1	XenobioticsIBA 12/2007
1	Cadherins (E-Cadherin)IBA 12/2007
1	Trastuzumab (Herceptin)FDA Link 10/2007
1	CD40 Ligand (CD40L)IBA 06/2007
1	Messenger RNA (mRNA)IBA 06/2007
1	Mitogen-Activated Protein KinasesIBA 05/2006
1	gallocatechol (epigallocatechin)IBA 05/2006
1	Dimethyl Sulfoxide (DMSO)FDA LinkGeneric 03/2006
1	NF-KappaB Inhibitor alphaIBA 11/2005
1	Cyclin-Dependent Kinase Inhibitor p27IBA 08/2005
1	Retinoblastoma ProteinIBA 01/2005
1	Peptidylprolyl Isomerase (Prolyl Isomerase)IBA 01/2005
1	Estrogen Receptor Modulators (Antiestrogen)IBA 10/2004

Therapy/Procedure

5	Therapeutics 09/2009 - 02/2002
1	Lab-On-A-Chip Devices 03/2016
1	Drug Therapy (Chemotherapy) 12/2010
1	Immunotherapy 10/2007